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  • Series of 5'-Nucleotides




    Nucleotides are the basic structural units of RNA and DNA. A nucleotide is composed of a nucleic acid base (nitrogenous base) and a five-carbon sugar (either ribose or 2'-deoxyribose), and one to three phosphate groups. Additionally, nucleotides play central roles in the genetics, growth and development of organism.


    The resent researches from both home and broad showed that exogenous nucleotides can greatly affect the growth of gastrointestinal tract of animals and the function of immune system, liver and neuron etc. Only nucleotides supplements can ensure the normal metabolism of organism in special conditions, so nucleotides which are regarded as a kind of special additives and intermediate, which have been widely applied in the fields of food, drug and feed.


    1. Drug Intermediates
     

    Degradation products of RNA (Nucleotides, nucleosides and nucleic acid bases) are all medicines with a wide application, and their derivatives have more remarkable application in the fields of antivirus and anti tumors. It has been widely applied in the treatment of hepatitis, gastritis, coronary heart disease, rheumatoid arthritis, leukocytopenia, cerebral concussion, angiocardiopathy etc.
     

    2. Food Additives
     

    Milk powder added with nucleotides not only can improve the development of gastrointestinal tract of infants, but also improve the immunological function of intestinal cells so that build up the resistance to bacterial infection. The addition of nucleotides into functional foods would help people delay aging, extend life and improve immunity etc. Additionally, there has been a wide application of flavor nucleotides in food seasoning.
     

    3. Feed Additives
     

    Nucleotide is a kind of non-toxic and harmless feed additive, improving animal's immune, gastrointestinal function and fat metabolism. Such as, nucleotides can increase the feed rate of pig, improve laying rate of chicken, promoting the growth and reproduction of fishes and aquatic animals.

    Series of 5
  • Series of Fructose-1,6-diphosphate


     

    FDP is an important intracellular intermediate of metabolism that controls the activities of some key enzymes in glyco-metabolism, and repairs and improves cell metabolism at the molecular level. With effective whole-cell catalysis, bio-separation, and crystallization techniques, we obtain high-quality FDP products.

     

    Application

    1. Used as an intermediate for producing drugs in FDP salts form.

    2. Used in food additives and healthy foods, replenishing the trace elements those are necessary substances for normal growth.

    3. Used in feed additives for promoting animals' growth and keeping them healthy.

    4. Used in clinical treatment, or adjunctive treatment, of osteoporosis and male sexual dysfunction.

    Series of Fructose-1,6-diphosphate
  • α-Amylase Inhibitor, wheat origin


     

    α-Amylase Inhibitor can inhibit the activity of amylase, which is secreted from the pancreas, in the intestine and can block/deter its digestive ability for starch, whose main component is carbohydrate. Thus, blood sugar reduced, and the increase in the blood sugar concentration is inhibited, which is beneficial in diabetic therapy. With an effective active chaperone, discovered by our company, the half-life ofα-Amylase Inhibitor activity is greatly prolonged.
     

    Application

    It is used as drugs and health food additives for weight reduction to prevent and treat of adiposity, lipomatosis, atherosclerosis, hyperlipidemia, and diabetes.

    α-Amylase Inhibitor, wheat origin
  • Casein Phosphopeptides, CPP


     

    Casein Phosphopeptides, CPP is one of functional food additives, which is the digest of casein. It can enhance the solubility of minerals, like calsium, ferrum, zinc, magnesium and so on, and their absorption in the digestive tract. It also can increase bones mass, prevent tooth decay, improve the capacity of animal breeding, improve the body immunity, and induce apoptosis.
     

    Application

    1. Used as food additive. CPP can be used as nutrients added to food or health food products.

    2. Used as pharmaceutical raw material.

    3. Used in toothpaste, mouthwash tablets and oral fluid. To protect teeth, and to prevent dental caries.

    4. Used to promote capacity of animal breeding.

    5. Used as feed additive. CPP can be used to produce animal health feed of specific physiological stage.

    Casein Phosphopeptides, CPP
  • Citicoline Sodium, CDPC


     

    Citicoline Sodium, CDPC is endogenous intermediate of phosphatidylcholine synthesis, and an essential element in biological membrane construction. After injury of nerve, it involves in repair and regeneration of nerve, which can protect nerve. Citicoline Sodium also plays a vital role in transfer of nerve agents and conduction of biological electricity. It has significant clinical therapeutic effect on acute stroke nerve injury caused by surgery, disturbance of consciousness, Parkinson's syndrome, dementia, and glaucoma.


    Application

    The main indications of Citicoline Sodium are acute traumatic brain injury and brain consciousness after the operation. Moreover, Citicoline Sodium can treat central nervous system dysfunction and unconsciousness caused by acute injury, paralysis agitans, tinnitus and nerve deafness, and poisoning caused by sleeping pills. In recent years, Citicoline Sodium is widely used in clinical for treatment of ischemic stroke, cerebral arteriosclerosis, multi-infarct dementia, Alzheimer's disease, and children viral encephalitis.

    Citicoline Sodium, CDPC
  • S-Ademetionine, SAM


     

    S-Ademetionine is a coenzyme found in all eukaryotic cells. SAM is a active form of methionine,animals, and it is an important metabolic intermediate in animals and plants. It also play a vital role in the human body as physiological active substance involved in more than 40 kinds of biochemical reactions. SAM is an essential donor of methyl group in cell. Its physiological function is transferring methyl, aminopropyl and sulfur group.


    Application

    S-Ademetionine is mainly used for the treatment of osteoarthritis (OA), depression, liver diseases such as viral hepatitis, cholestasis, liver damage caused by alcohol, liver cirrhosis and some other liver dysfunctions. It also can increase infertile men's sperm vitality, be used to treat migraines, alleviate the sequela of cerebral concussion symptoms, and have effect on muscle fiber pain and coronary heart disease.

    S-Ademetionine, SAM
  • Adenosine Cyclphosphate, cAMP

    Cyclic AMP



    CAS:60-92-4

    EINECS:200-492-9


    Updated Time2009.08.29
    Synonyms

    3'-5' Cyclic adenosine monophosphate

    Molecular Formula

    C10H12N5O6P

    Molecular Weight

    329.21
    | View Times:804
    Adenosine Cyclphosphate, cAMP
  • New products




     

    New products
  • The Source of Technology


    The production technology of BioTogether relies on National Engineering Research Center for Biotechnology (NERCB).

    Our core production technology roots in the second prize of National Award  for Technical Invention , namely, producing high-energy phosphorylated compounds with new technologies of biological phosphorylation.

    High Efficient Bioenzymolysis
    To solve the problem of low-effective substrate utilization and low-yield product.

    High Efficiency Bioseparation
    To solve the problem of low-effective separation serious environment pollution ,high energy-consumption, low Product yield and high production cost.

    Bio-Product Refinery
    To solve the problem of difficult crystallization、complex process and poor quality of products.


     

    Science and Technology Innovation

    We have made several major breakthroughs in key technologies of Nucleotide production, such as the selection and modification of Penicillium citrinum strain that produces P1 nuclease, enzymatic hydrolysis of RNA, the separation of four nucleotides in the same column and their crystallization. On these bases, BioTogether has formed its independent intellectual property rights in production technology, and its technical and economic indicators have reached international advanced level.

    (1) Obtaining high-yielding strain by using ion beam inducing mutation. The strain has a good stability (the technology has applied for invention patents of China CN200710022932.6).

    The 5'-nucleotides are produced by enzymolysis of RNA using P1 nuclease which is obtained by Penicillium citrinum’s fermentation instead of being extracted from malt root. Malt roots contain many poisoning substances hazardous to health, such as N-methyl hordenines, nitrosamines, patulin, aspergillus oryzae and nettle Penicillium, whereas the fermentation of Penicillium citrinum to produce P1 nuclease can avoid a security risk effectively.

    (2) Replacing of traditional stirred-tank and solid-state fermentation, the application of new air-lift fermentation to, greatly simplified production process of nuclease, and significantly shortening the production cycle.

    (3)Had synthesized a new separation medium nucleotides, the application of new separation technologies - adsorption - the separation of membrane separation technology integration nucleotide, so that the separation yield of more than 93 percent, energy consumption, a significant reduction in pollutant emissions; (The technique had been applied for invention patent of China CN200610085403.6).

    (4) We have invented a complex technique of alcohol-precipitation and salting-out crystallization, conducing the yield of four kinds of nucleotides greater than 90%, and product quality is in line with the requirements of large international companies. (The technique was applied in invention patent of China CN200610085394.0, CN200610085381.3)


     

    Company Patents

    China Patents (Granted):

    ZL200510094956.3
    ZL200410041455.4
    ZL200610085382.8
    ZL200510095770.x
    ZL01127286.4
    ZL00112022.0
    ZL93110527.7
    ZL200510040104.6

    China Patents(Filed):

    25 items.


     

    Projects Undertaking

    National “863” project in 2006

    Major technological innovation project of Jiangsu Province in 2006

    Project of Science and Technology Innovation Fund of Nanjing City in 2008

    Planning Projects of Jiangsu Province and Nanjing City in 2009

    Projects of Enterprises’ Technology Development of Nanjing City in 2009

    Projects of Science and Technology program of Nanjing City in 2009

    Projects of scientific and technological achievements’ Transformation of Jiangsu Province in 2009

    Expertise

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